SrasV1, Main, Exploration, bibRecord, 006412

Coronavirus as a possible cause of severe acute respiratory syndrome. Commentary

Identifieur interne : 006412 ( Main/Exploration ); précédent : 006411; suivant : 006413

Coronavirus as a possible cause of severe acute respiratory syndrome. Commentary

Auteurs : J. S. M. Peiris [Hong Kong] ; S. T. Lai [Hong Kong] ; L. L. M. Poon [Hong Kong] ; Y. Guan [Hong Kong] ; L. Y. C. Yam [Hong Kong] ; W. Lim [Hong Kong] ; J. Nicholls [Hong Kong] ; W. K. S. Yee [Hong Kong] ; W. W. Yan [Hong Kong] ; M. T. Cheung [Hong Kong] ; V. C. C. Cheng [Hong Kong] ; K. H. Chan [Hong Kong] ; D. N. C. Tsang [Hong Kong] ; R. W. H. Yung [Hong Kong] ; T. K. Ng [Hong Kong] ; K. Y. Yuen [Hong Kong] ; Ann R. Falsev [États-Unis] ; Edward E. Walsh [États-Unis]

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2003.

RBID : Pascal:03-0249472

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Coronavirus (), Coronavirus (isolement et purification), Coronavirus (ultrastructure), Culture virale, Facteurs de risque, Femelle, Hong Kong, Humains, Infections opportunistes (diagnostic), Infections opportunistes (transmission), Infections opportunistes (virologie), Infections à coronavirus (diagnostic), Infections à coronavirus (transmission), Infections à coronavirus (virologie), Microscopie électronique, Mâle, Partie nasale du pharynx (virologie), RT-PCR, Sujet âgé, Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (transmission), Syndrome respiratoire aigu sévère (virologie), Évolution de la maladie.
MESH :
- diagnostic : Infections opportunistes, Infections à coronavirus, Syndrome respiratoire aigu sévère.
- isolement et purification : Coronavirus.
- virologie : Infections opportunistes, Infections à coronavirus, Partie nasale du pharynx, Syndrome respiratoire aigu sévère.
Pascal (Inist)
- Adulte, Adulte d'âge moyen, Coronavirus, Culture virale, Facteurs de risque, Femelle, Hong Kong, Humains, Infections opportunistes, Infections à coronavirus, Microscopie électronique, Mâle, RT-PCR, Sujet âgé, Syndrome respiratoire aigu sévère, Virose, Symptomatologie, Pneumonie, Atypique, Etiologie, Homme, Hong Kong, Epidémiologie, Évolution de la maladie.
Wicri :
- geographic : Hong Kong.
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Atypical, Coronavirus, Coronavirus (classification), Coronavirus (isolation & purification), Coronavirus (ultrastructure), Coronavirus Infections (diagnosis), Coronavirus Infections (transmission), Coronavirus Infections (virology), Disease Progression, Epidemiology, Etiology, Female, Hong Kong, Human, Humans, Male, Microscopy, Electron, Middle Aged, Nasopharynx (virology), Opportunistic Infections (diagnosis), Opportunistic Infections (transmission), Opportunistic Infections (virology), Pneumonia, Reverse Transcriptase Polymerase Chain Reaction, Risk Factors, Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (transmission), Severe Acute Respiratory Syndrome (virology), Symptomatology, Viral disease, Virus Cultivation.
MESH :
- geographic : Hong Kong.
- classification : Coronavirus.
- diagnosis : Coronavirus Infections, Opportunistic Infections, Severe Acute Respiratory Syndrome.
- isolation & purification : Coronavirus.
- transmission : Coronavirus Infections, Opportunistic Infections, Severe Acute Respiratory Syndrome.
- ultrastructure : Coronavirus.
- virology : Coronavirus Infections, Nasopharynx, Opportunistic Infections, Severe Acute Respiratory Syndrome.
- Adult, Aged, Disease Progression, Female, Humans, Male, Microscopy, Electron, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction, Risk Factors, Virus Cultivation.

Abstract

Background An outbreak of severe acute respiratory syndrome (SARS) has been reported in Hong Kong. We investigated the viral cause and clinical presentation among 50 patients. Methods We analysed case notes and microbiological findings for 50 patients with SARS, representing more than five separate epidemiologically linked transmission clusters. We defined the clinical presentation and risk factors associated with severe disease and investigated the causal agents by chest radiography and laboratory testing of nasopharyngeal aspirates and sera samples. We compared the laboratory findings with those submitted for microbiological investigation of other diseases from patients whose identity was masked. Findings Patients' age ranged from 23 to 74 years. Fever, chills, myalgia, and cough were the most frequent compiaints. When compared with chest radiographic changes, respiratory symptoms and auscultatory findings were disproportionally mild. Patients who were household contacts of other infected people and had older age, lymphopenia, and liver dysfunction were associated with severe disease. A virus belonging to the family Coronaviridae was isolated from two patients. By use of serological and reverse-transcriptase PCR specific for this virus, 45 of 50 patients with SARS, but no controls, had evidence of infection with this virus. Interpretation A coronavirus was isolated from patients with SARS that might be the primary agent associated with this disease. Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.

Affiliations:

Hong Kong, États-Unis

Le document en format XML

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<country>Hong Kong</country>
<wicri:noRegion>Department of Microbiology and Pathology, Queen Mary Hospital, University of Hong Kong</wicri:noRegion>
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<author><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K. H." last="Chan">K. H. Chan</name>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Microbiology and Pathology, Queen Mary Hospital, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsang, D N C" sort="Tsang, D N C" uniqKey="Tsang D" first="D. N. C." last="Tsang">D. N. C. Tsang</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Pathology, Queen Elizabeth Hospital</s1>
<s3>HKG</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, Queen Elizabeth Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yung, R W H" sort="Yung, R W H" uniqKey="Yung R" first="R. W. H." last="Yung">R. W. H. Yung</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine and Pathology, Pamela Youde Nethersole Eastern Hospital</s1>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Medicine and Pathology, Pamela Youde Nethersole Eastern Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ng, T K" sort="Ng, T K" uniqKey="Ng T" first="T. K." last="Ng">T. K. Ng</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Intensive Care and Pathology, Princess Margaret Hospital</s1>
<s3>HKG</s3>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Medicine, Intensive Care and Pathology, Princess Margaret Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology and Pathology, Queen Mary Hospital, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Microbiology and Pathology, Queen Mary Hospital, University of Hong Kong</wicri:noRegion>
</affiliation>
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<author><name sortKey="Falsev, Ann R" sort="Falsev, Ann R" uniqKey="Falsev A" first="Ann R." last="Falsev">Ann R. Falsev</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Rochester General Hospital, University of Rochester School of Medicine and Dentistry</s1>
<s2>Rochester NY 1462</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>Rochester NY 1462</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Walsh, Edward E" sort="Walsh, Edward E" uniqKey="Walsh E" first="Edward E." last="Walsh">Edward E. Walsh</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Rochester General Hospital, University of Rochester School of Medicine and Dentistry</s1>
<s2>Rochester NY 1462</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>Rochester NY 1462</wicri:noRegion>
</affiliation>
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<series><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="2003">2003</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Atypical</term>
<term>Coronavirus</term>
<term>Coronavirus (classification)</term>
<term>Coronavirus (isolation & purification)</term>
<term>Coronavirus (ultrastructure)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (transmission)</term>
<term>Coronavirus Infections (virology)</term>
<term>Disease Progression</term>
<term>Epidemiology</term>
<term>Etiology</term>
<term>Female</term>
<term>Hong Kong</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Microscopy, Electron</term>
<term>Middle Aged</term>
<term>Nasopharynx (virology)</term>
<term>Opportunistic Infections (diagnosis)</term>
<term>Opportunistic Infections (transmission)</term>
<term>Opportunistic Infections (virology)</term>
<term>Pneumonia</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Risk Factors</term>
<term>Severe Acute Respiratory Syndrome (diagnosis)</term>
<term>Severe Acute Respiratory Syndrome (transmission)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Symptomatology</term>
<term>Viral disease</term>
<term>Virus Cultivation</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Coronavirus ()</term>
<term>Coronavirus (isolement et purification)</term>
<term>Coronavirus (ultrastructure)</term>
<term>Culture virale</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Hong Kong</term>
<term>Humains</term>
<term>Infections opportunistes (diagnostic)</term>
<term>Infections opportunistes (transmission)</term>
<term>Infections opportunistes (virologie)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (transmission)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Microscopie électronique</term>
<term>Mâle</term>
<term>Partie nasale du pharynx (virologie)</term>
<term>RT-PCR</term>
<term>Sujet âgé</term>
<term>Syndrome respiratoire aigu sévère (diagnostic)</term>
<term>Syndrome respiratoire aigu sévère (transmission)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hong Kong</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
<term>Opportunistic Infections</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections opportunistes</term>
<term>Infections à coronavirus</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term>
<term>Opportunistic Infections</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections opportunistes</term>
<term>Infections à coronavirus</term>
<term>Partie nasale du pharynx</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Nasopharynx</term>
<term>Opportunistic Infections</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Microscopy, Electron</term>
<term>Middle Aged</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Risk Factors</term>
<term>Virus Cultivation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Coronavirus</term>
<term>Culture virale</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Hong Kong</term>
<term>Humains</term>
<term>Infections opportunistes</term>
<term>Infections à coronavirus</term>
<term>Microscopie électronique</term>
<term>Mâle</term>
<term>RT-PCR</term>
<term>Sujet âgé</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virose</term>
<term>Symptomatologie</term>
<term>Pneumonie</term>
<term>Atypique</term>
<term>Etiologie</term>
<term>Homme</term>
<term>Hong Kong</term>
<term>Epidémiologie</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Hong Kong</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Background An outbreak of severe acute respiratory syndrome (SARS) has been reported in Hong Kong. We investigated the viral cause and clinical presentation among 50 patients. Methods We analysed case notes and microbiological findings for 50 patients with SARS, representing more than five separate epidemiologically linked transmission clusters. We defined the clinical presentation and risk factors associated with severe disease and investigated the causal agents by chest radiography and laboratory testing of nasopharyngeal aspirates and sera samples. We compared the laboratory findings with those submitted for microbiological investigation of other diseases from patients whose identity was masked. Findings Patients' age ranged from 23 to 74 years. Fever, chills, myalgia, and cough were the most frequent compiaints. When compared with chest radiographic changes, respiratory symptoms and auscultatory findings were disproportionally mild. Patients who were household contacts of other infected people and had older age, lymphopenia, and liver dysfunction were associated with severe disease. A virus belonging to the family Coronaviridae was isolated from two patients. By use of serological and reverse-transcriptase PCR specific for this virus, 45 of 50 patients with SARS, but no controls, had evidence of infection with this virus. Interpretation A coronavirus was isolated from patients with SARS that might be the primary agent associated with this disease. Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.</div>
</front>
</TEI>
<affiliations><list><country><li>Hong Kong</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="Hong Kong"><noRegion><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name>
</noRegion>
<name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K. H." last="Chan">K. H. Chan</name>
<name sortKey="Cheng, V C C" sort="Cheng, V C C" uniqKey="Cheng V" first="V. C. C." last="Cheng">V. C. C. Cheng</name>
<name sortKey="Cheung, M T" sort="Cheung, M T" uniqKey="Cheung M" first="M. T." last="Cheung">M. T. Cheung</name>
<name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name>
<name sortKey="Lai, S T" sort="Lai, S T" uniqKey="Lai S" first="S. T." last="Lai">S. T. Lai</name>
<name sortKey="Lim, W" sort="Lim, W" uniqKey="Lim W" first="W." last="Lim">W. Lim</name>
<name sortKey="Ng, T K" sort="Ng, T K" uniqKey="Ng T" first="T. K." last="Ng">T. K. Ng</name>
<name sortKey="Nicholls, J" sort="Nicholls, J" uniqKey="Nicholls J" first="J." last="Nicholls">J. Nicholls</name>
<name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L. L. M." last="Poon">L. L. M. Poon</name>
<name sortKey="Tsang, D N C" sort="Tsang, D N C" uniqKey="Tsang D" first="D. N. C." last="Tsang">D. N. C. Tsang</name>
<name sortKey="Yam, L Y C" sort="Yam, L Y C" uniqKey="Yam L" first="L. Y. C." last="Yam">L. Y. C. Yam</name>
<name sortKey="Yan, W W" sort="Yan, W W" uniqKey="Yan W" first="W. W." last="Yan">W. W. Yan</name>
<name sortKey="Yee, W K S" sort="Yee, W K S" uniqKey="Yee W" first="W. K. S." last="Yee">W. K. S. Yee</name>
<name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name>
<name sortKey="Yung, R W H" sort="Yung, R W H" uniqKey="Yung R" first="R. W. H." last="Yung">R. W. H. Yung</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Falsev, Ann R" sort="Falsev, Ann R" uniqKey="Falsev A" first="Ann R." last="Falsev">Ann R. Falsev</name>
</noRegion>
<name sortKey="Walsh, Edward E" sort="Walsh, Edward E" uniqKey="Walsh E" first="Edward E." last="Walsh">Edward E. Walsh</name>
</country>
</tree>
</affiliations>
</record>

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Coronavirus as a possible cause of severe acute respiratory syndrome. Commentary

Coronavirus as a possible cause of severe acute respiratory syndrome. Commentary

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